在Kratom消费者中使用Kratom使用障碍的普遍性
Katherine Hill1, Oliver Grundmann, Kirsten E Smith
1From the Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT (KH); College of Pharmacy, Department of Medicinal Chemistry, University of Florida, Gainesville, FL (OG); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD (KES); New Hampshire Hospital, Concord, NH (CNS); Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH (CNS); and Geisel School of Medicine, Dartmouth College, Hanover, NH (CNS).
Kratom使用障碍 (KUD) 影响超过四分之一的消费者,耐受性和戒断是常见的症状. 频繁使用和同时出现的疾病会增加KUD的风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 克拉叶产品在美国越来越受欢迎,用户报告了好处.
- 人们担心,定期使用kratom可能会导致依赖.
研究的目的:
- 评估 kratom 消费者中使用 kratom 障碍 (KUD) 的流行率.
- 精神障碍的使用诊断和统计手册,第五版 (DSM-5) 对物质使用障碍的标准,适用于kratom.
主要方法:
- 从2023年2月到5月,通过匿名在线调查进行了一项横截面研究.
- 非概率抽样招募了超过18岁的当前 kratom 消费者.
- 收集了关于KUD的消费模式,感知不良影响,并发症和DSM-5标准的数据.
主要成果:
- 在2061名参与者中,25.5%符合KUD.标准.
- 最常见的症状是耐受性 (81.3%) 和戒断性 (68.0%).
- 同时使用物质障碍显著增加了满足KUD标准的几率 (OR 2.83,95% CI 2.19-3.67).
结论:
- 大多数符合KUD标准的个体的诊断是轻度或中度.
- 与KUD相关的因素包括男性性别,年龄较小,频繁食用kratom,以及精神病/物质使用障碍并发症.
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