和COVID-19相关住院和死亡的风险:一项人口研究
Huw Strafford1, Joe Hollinghurst1, Arron S Lacey1
1Faculty of Medicine, Health, and Life Science, Swansea University Medical School, Swansea University, Swansea, UK.
患有 (PWE) 的人面临COVID-19住院和死亡的风险增加了一倍. 即使考虑到其他健康状况,这种增加的风险仍然存在,这凸显了针对性健康策略的必要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 患有 (PWE) 的人可能有更高的COVID-19严重后果的风险.
- 鉴定这种风险对于PWE和公共卫生规划至关重要.
研究的目的:
- 与普通人口相比,评估PWE中COVID-19住院和死亡的风险.
- 为PWE提供信息并指导未来的健康和护理策略.
主要方法:
- 使用来自威尔士SAIL数据库 (3.1百万人口) 的链接电子健康记录进行的回顾性队列研究.
- 确定了27,279个PWE,并根据性别,年龄和社会经济地位将它们与对照 (5:1比) 相匹配.
- 使用考克斯比例危险模型计算COVID-19死亡和住院的危险比率,调整为并发症.
主要成果:
- 与对照组相比,PWE的COVID-19死亡率 (0.58%) 和住院率 (3.4%) 较高 (分别为0.27%和1.4%).
- 在PWE中,死亡和住院的未经调整的危险比为两种结果的2.15.
- 在PWE中,死亡和住院的调整后危险比分分别为1.32和1.60.
结论:
- 与匹配的对照组相比,PWE的住院和死于COVID-19的风险显著增加.
- 这种高风险即使经过对伴随性疾病进行调整后仍然存在,这突显了PWE的脆弱性.
- 研究结果表明,对于未来的COVID-19治疗和疫苗接种策略,应优先考虑PWE.
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