相关实验视频
Updated: Jul 1, 2025

04:27
Intratracheal Instillation of Stem Cells in Term Neonatal Rats
Published on: May 4, 2020
5.6K
在早产婴儿少侵入性表面活性剂施用期间进行鼻间断正压通风:一项开放式随机对照研究
Carlo Dani1,2, Marcello Napolitano3, Ciro Barone3
1Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy.
Pediatric pulmonology
|March 5, 2024
概括
在较少侵入性表面活性剂治疗 (LISA) 期间的鼻间歇性正压通风 (NIPPV) 与鼻持续正气道压力 (NCPAP) 相比,并没有改善非常早产婴儿的呼吸结果. 这两种方法都是安全的,但NIPPV在LISA期间没有显著的优势.
科学领域:
- 新生儿医学 新生儿医学
- 呼吸系统生理学 呼吸系统生理学
- 儿科重症监护 儿科重症监护
背景情况:
- 呼吸困扰综合征 (RDS) 影响了许多非常早产的婴儿,大约一半的婴儿未能接受最初的鼻腔连续正气道压力 (NCPAP) 治疗.
- 由于NCPAP的失败,通常需要机械通风 (MV),这增加了脆弱婴儿的风险.
研究的目的:
- 为了比较鼻间歇性正压通风 (NIPPV) 与NCPAP在较少侵入性表面活性剂治疗 (LIST) 期间改善呼吸结果的疗效.
- 评估LISA期间的NIPPV是否可以减少对机械通风或额外表面活性剂剂量的需求.
主要方法:
- 一个开放的随机对照试验,涉及200名非常早产婴儿 (25+0-31+6怀孕周) 患有RDS.
- 婴儿通过LISA接受了表面活性剂前后的NCPAP,其次是NIPPV或NCPAP.
- 主要终点:需要在72小时内进行第二剂表面活性剂或MV;次要终点包括呼吸支持续时间和氧化.
主要成果:
- 在NIPPV和NCPAP组之间的初级复合结果中没有显著差异 (OR 0.873;p=0.681).
- 与NCPAP加LISA相比,NIPPV加LISA的SpO2/FiO2比率显示出暂时的改善.与NCPAP加LISA相比,NIPPV加LISA的比率显示出暂时的改善.
- 与LISA相关的不良事件在两个治疗臂中发生的频率相似.
结论:
- 在LISA期间的NIPPV和NCPAP在非常早产婴儿的短期呼吸结果中同样安全有效.
- 这项研究不支持在LISA期间对这一人群进行常规使用NIPPV而不是NCPAP.
更多相关视频
相关概念视频
Mechanical Ventilation III: Noninvasive Ventilation
112
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
112
Mechanical Ventilation II: Invasive Ventilation
133
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
133
Suctioning the Nasopharyngeal Airway
407
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
407
Breathing
59.2K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.2K
Ventilatory Modes
144
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
144
Endotracheal Intubation I: Procedure
1.3K
Endotracheal or ET intubation is a critical medical procedure used to secure a patient's airway, often in acute respiratory distress, apnea, upper airway obstruction, ineffective clearance of secretions, high risk for aspiration, or during general anesthesia.
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
1.3K

