多发性硬化症患者皮质网络非损伤损伤的认知相关性
Eva A Krijnen1,2,3, Tommy A A Broeders4, Samantha Noteboom4
1MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, 1007 MB, Amsterdam, The Netherlands. e.a.krijnen@amsterdamumc.nl.
Journal of neurology
|March 5, 2024
概括
多发性硬化症 (MS) 的认知障碍与皮质损伤有关. 非损伤性皮质的扩散变化,特别是默认模式网络,在认知受损的多发性硬化症患者中更为突出.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 神经学 神经学
背景情况:
- 认知障碍是多发性硬化症 (MS) 的重要症状,通常与皮质损伤有关.
- 区域皮质损伤对MS认知的具体影响尚不清楚.
研究的目的:
- 评估MS患者的损伤和非损伤皮质的结构完整性.
- 调查皮层完整性与MS认知功能障碍之间的关系.
主要方法:
- 与176名多发性硬化患者和48名健康对照进行的横截面研究.
- 进行了MRI (双反转恢复,扩散加权扫描) 和神经心理评估.
- 在212个区域使用分数异构 (FA) 和平均扩散率 (MD) 评估皮质完整性,分为病变或非病变,并分为七个皮质网络.
主要成果:
- 在87.5%的MS患者中存在皮层病变,主要存在于腹部注意力,边缘和默认模式网络中.
- 与对照人群相比,MS患者在非损伤性皮质中显示出平均扩散率 (MD) 的增加,平均分数异构 (FA) 没有差异.
- 损伤性皮层在个体内表现出比非损伤性皮层更高的MD和FA. 认知障碍 (CI) MS患者的非损伤性皮质MD比认知保存 (CP) MS患者高,特别是在默认模式网络中.
结论:
- 扩散差异在损伤性皮层比非损伤性皮层更严重.
- 尽管病变很常见,但CI-MS中的扩散差异在非病变性皮质中更为明显,特别是在默认模式,前对对面和感觉运动网络中.
- 默认模式网络完整性与MS患者的认知表现最强烈相关.
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