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儿童常规黑色素瘤亚型的区域淋巴结评价:单中心10年审查

Pattamon Sutthatarn^1,2, Andrew M Davidoff^1,3, Armita Bahrami⁴

¹Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

Pediatric surgery international

|March 5, 2024

概括

哨兵淋巴结活检 (SLNB) 对儿科黑色素瘤至关重要,因为积极的结果和诊断时的年龄预测复发. 完成淋巴结解剖 (CLND) 没有显著的益处.

科学领域:

儿科瘤学儿科瘤学
皮肤病学皮肤病学
手术瘤学手术瘤学

背景情况:

儿童常规黑色素瘤 (CM) 需要了解预后因素.
哨兵淋巴结活检 (SLNB) 是一个关键的分期程序.
完成淋巴结解剖 (CLND) 是随后的手术选择.

研究的目的:

评估SLNB和CLND在儿科CM中的预后和治疗影响.
为了确定儿科黑色素瘤患者的预测结果的预测因素.

主要方法:

从2009年至2020年对医疗记录的回顾性分析.
包括18岁或更年轻的局部皮肤CM患者.
分析转移检测率,复发风险,无疾病生存率 (DFS) 和总生存率 (OS).

主要成果:

在57.6%的儿科CM病例中,SLNB检测到转移.
阳性SLN状态与明显更高的复发风险相关 (HR5.92,P=0.024).
诊断时的年龄与复发风险相关 (每年危险增加21%).

结论:

阳性SLN状态和在诊断时的年龄较大与儿科CM中更糟糕的DFS有关.
在这个队列中,CLND没有显示出预后或治疗价值.
建议进一步进行多中心试验,以验证这些发现.

关键词:

黑色素瘤是一种黑色素瘤.儿科黑色素瘤的发生哨兵淋巴模式活检检查斯皮茨黑色素瘤是什么意思

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