相关实验视频

Updated: Jul 1, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

CheekAge:与生活方式和健康相关的下一代口腔表观遗传衰老时钟

Maxim N Shokhirev¹, Nicole S Torosin¹, Daniel J Kramer¹

¹Tally Health, New York, NY, USA.

|March 5, 2024

概括

研究人员开发了CheekAge,这是一个新的表观遗传衰老时钟,使用从脸上取的DNA甲基化. 这个时钟准确地预测年龄,并与健康和生活方式因素相关联,提供一种非侵入性的衰老生物标志物.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
生物标志物开发生物标志物开发
计算生物学计算生物学

背景情况:

表观遗传衰老时钟使用DNA甲基化预测生物年龄.
第一代时钟使用了与年龄相关的CpG;下一代时钟结合了健康和生活方式因素.
现有的时钟主要是通过血液进行训练,限制了对非侵入性样本的应用.

研究的目的:

开发一个下一代表观遗传时钟,优化用于脸抽样.
从容易收集的样本创建一个准确和可重复的衰老生物标志物.
研究表观遗传年龄与健康和生活方式在多样化的成年人群中的关联.

主要方法:

收集了8045名成年人的甲基化EPIC数据和健康/生活方式信息.
在培训中采用了一种新的模拟回火方法,并结合了健康和生活方式因素.
使用CpG过,聚类和时钟组合来构建CheekAge时钟.

主要成果:

脸年龄与时间年龄有很强的相关性.
时钟显示了高的测试-重新测试可重复性.
由CheekAge预测的表观遗传年龄与BMI,吸烟状况和酒精摄入量显著相关.

结论:

脸年龄是一种经过验证的表观遗传钟,用于脸抽样,提供可靠的生物年龄测量.
时钟与健康和生活方式因素的关联凸显了它作为健康生物标志物的潜力.
有一个免费的在线工具可用于访问甲基组数据和预测表观遗传年龄.

关键词:

老化的时钟钟.嘴唇的口腔是什么意思组合学习学习组合学习表观遗传年龄表观遗传年龄机器学习是机器学习.模拟的回火模拟

更多相关视频

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

相关概念视频

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...