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Updated: Jul 1, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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在慢性炎症中,TGF-β1通过SMAD3/STAT3合作信号在巨细胞中诱导PD-1表达

Zhigang Lei1, Rui Tang2, Yu Wu1

  • 1State Key Laboratory of Reproductive Medicine and Offspring Health, National Vaccine Innovation Platform of Nanjing Medical University, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.

JCI insight
|March 5, 2024
PubMed
概括

转化生长因子-β1 (TGF-β1) 在慢性炎症期间在巨细胞上直接诱导编程细胞死亡蛋白1 (PD-1). 这种TGF-β1触发的信号通路,涉及SMAD3和STAT3,调节巨细胞功能和免疫反应.

关键词:
免疫学 免疫学 免疫学炎症 炎症是一种炎症.巨细胞是一个巨细胞.

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