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相关概念视频

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

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When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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相关实验视频

Updated: Jul 1, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
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Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

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目前用于高极化[1-13C]pyruvate MRI 人体研究的方法.

Peder E Z Larson1,2, Jenna M L Bernard1, James A Bankson3

  • 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Magnetic resonance in medicine
|March 5, 2024
PubMed
概括
此摘要是机器生成的。

超极化 (HP) 13CMRI使用专门的药物来测量癌症等疾病中的新陈代谢. 本指南详细介绍了使用HP13C-pyruvateMRI对人类研究的最佳实践.

关键词:
碳-13,可以说是碳-13了.溶解动态的核极化 动态的核极化超极化核磁共振成像 (MRI) 是一种超极化的核磁共振成像.代谢成像 - - 代谢成像皮鲁酸是一种

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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

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相关实验视频

Last Updated: Jul 1, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
14:56

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

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科学领域:

  • 医疗成像医学成像
  • 代谢成像 - 代谢成像
  • 超极化核磁共振成像 (MRI) 是一种超极化的核磁共振成像.

背景情况:

  • 超极化 (HP) 13C MRI测量疾病中局部代谢的变化.
  • 在过去的十年中,由于HP剂制备的改进,人体研究迅速增长.
  • 13C-pyruvate是最常见的代理,对研究糖解至关重要.

研究的目的:

  • 概述目前人类HP13CMRI研究的成功实践.
  • 专注于 [1-13C]酸盐,这是一个关键的代谢标记物.
  • 为不断发展的代谢成像领域提供全面的参考资料.

主要方法:

  • 涵盖HP13的C-pyruvate制备方法.
  • 详细说明MRI系统的设置和校准协议.
  • 解释数据采集,图像重建和分析技术.

主要成果:

  • 确定了成功的HP13CMRI研究的关键组成部分.
  • 总结了已发表的研究和当前的临床实践.
  • 讨论证据缺口,优势和限制的模式.

结论:

  • 建立了关于人类HP13C MRI最佳实践的共识.
  • 旨在指导未来的代谢成像研究和开发.
  • 突出了HP13CMRI在诊断和监测各种疾病方面的潜力.