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Multi-species Conserved Sequences02:51

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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在海绵基因组中的短宏环.

Zhenjian Lin1, Vinayak Agarwal2,3, Ying Cong1

  • 1Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112.

Proceedings of the National Academy of Sciences of the United States of America
|March 5, 2024
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海绵产生独特的富含proline的宏循环 (PRMPs),与细菌不同. 这一发现揭示了一个新的生物活性化合物类别,在动物信号传递和翻译后修改中具有潜在的作用.

关键词:
在RIPP中,RIPP是指RIPP.圆形的质是圆形的质.这是一种循环类.甲动物生物合成这些是海绵,海绵.

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科学领域:

  • 海洋生物学 海洋生物学
  • 生物化学 生物化学
  • 基因组学就是基因组学.

背景情况:

  • 海洋海绵 (Porifera) 是已知的生物活性的来源,共生细菌传统上被认为产生了许多生物活性.
  • 核糖体合成和翻译后修饰 (RiPPs) 和非核糖体是已确立的海绵相关代谢物的类别.

研究的目的:

  • 研究海绵自身生产生物活性的能力,特别是富含proline的宏环 (PRMPs).
  • 在海绵基因组和转录组中识别和描述新型PRMP及其前体.

主要方法:

  • 对海绵转录组 (Stylissa carteri) 和基因组 (Axinella corrugata) 的生物信息分析,以确定RiPP型核心序列.
  • 质谱测量以表征从A. corrugata中分离出来的循环.
  • 在具有和没有PRMP的海绵中对基因表达的比较分析.

主要成果:

  • 鉴定了来自S. carteri的46种不同的RiPP型核心,包括10种已知的PRMP.
  • 在A. corrugata中发现了35个PRMP前体,编码31个独特的核心序列.
  • 来自A. corrugata的11种循环的表征,包括新型型素胺 (A-D) 和7种未描述的化合物,证实动物起源.
  • PRMP海绵表现出潜在分泌的多的显著丰富 (>23,000信号基因).

结论:

  • 海绵本身是各种生物活性宏环的重要生产者,包括PRMPs.
  • PRMPs的生物合成逻辑与神经具有相似之处,这表明在动物之间信号修饰的保存机制.
  • 这一发现突显了动物衍生的信号和翻译后修改的潜在广泛和低估的多样性.