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稳定同位素的合成,三化,和碳-14标记的Balcinrenone

Jonas Bergare¹, Christopher Bailey², Henrik Sörensen³

¹Early Chemical Development Pharmaceutical Science, R&D, AstraZeneca, Gothenburg, Sweden.

Journal of labelled compounds & radiopharmaceuticals

|March 5, 2024

概括

研究人员合成了balcinrenone (AZD9977) 的标记版本,以研究其在治疗脏和心血管疾病中的用途. 这些标记的化合物对于临床生物分析和生物研究至关重要.

科学领域:

药用化学医学化学
药理学药理学是指药理学的学科.

背景情况:

矿物质皮质类受体调节剂正在针对脏和心血管疾病进行研究.
巴尔辛伦 (AZD9977) 是该治疗领域的化合物.

研究的目的:

为生物分析和生物研究准备稳定同位素标记版本的balcinrenone (AZD9977).
为了合成放射性标记的balcinrenone用于临床前和临床应用.

主要方法:

制备四个稳定同位素标记的balcinrenone版本.
三个稳定同位素标记化合物和母化合物的三度化.
碳-14标记的balcinrenone的合成使用标准的化-三化化方法.

主要成果:

成功合成了多个稳定的同位素和放射性标记的balcinrenone类似物.
标记的化合物适用于临床生物分析,生物研究以及药物代谢和药理动力学 (DMPK) 研究.

结论:

合成的标记Balcinrenone化合物是推动这种矿物质皮质类受体调节器临床开发的重要工具.
这些标记的化合物将支持全面调查Balcinrenone在脏和心血管疾病的疗效和安全性.

关键词:

AZD997777777777 AZD99777777777777777 AZD99777777777777 是一个非常好的医疗保健公司.良好的生理惯例 (GMP) 是一个好方法.标有标签的.哈德米 (HADME) 是一个人.

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