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Updated: Jul 1, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
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Published on: February 15, 2016

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设计,合成和抗瘤活动的2-替代的quinazoline-4-amine衍生物

Menghan Wang1, Jia Yu2, Xinyi Huang2

  • 1College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China.

Bioorganic & medicinal chemistry
|March 5, 2024
PubMed
概括

针对维纳综合征 (WRN) 蛋白质的新quinazoline-4-amine类似物显示出强大的抗癌活性. 化合物18b和23a有效地抑制癌细胞生长,特别是在WRN过度表达的细胞中,表明其作为新型WRN蛋白抑制剂的潜力.

关键词:
它具有抗癌活性.昆氨酸衍生物 昆氨酸衍生物结构设计 结构设计综合合成 综合合成在WRN中使用Helicaase.

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