D-β-基酸盐对克劳丁-1进行上调,并缓解了 lipopolysaccharide 治疗小鼠的肠道超透性
Ting Wang1, Yuchen Zhuang1, Chenglong Yu2
1Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Hebei, People's Republic of China.
Tissue & cell
|March 5, 2024
概括
在全身炎症中,D-β-基酸盐 (BHB) 可能会防止肠道屏障功能障碍. 在小鼠炎症模型中,BHB治疗改善了肠上皮质屏障功能,并增加了Claudin-1水平.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
背景情况:
- 肠上皮质的超透性有助于系统性炎症.
- 在炎症期间调节肠道屏障功能的D-β-基酸盐 (BHB) 的作用尚不清楚.
研究的目的:
- 为了研究BHB对肠表皮透性的影响,E-cadherin和Claudin-1在脂多糖 (LPS) 诱导的全身炎症小鼠模型中.
主要方法:
- 通过腹腔内LPS注射诱导系统性炎症的小鼠.
- BHB是通过口服给药,以评估其保护作用.
- 分析了肠道透性,结肠形态,E-cadherin和Claudin-1的表达和分布.
主要成果:
- LPS诱导了肠道的超透性,结肠炎症,扰乱了E-cadherin,并降低了Claudin-1.
- BHB治疗缓解了超透性,改善了结肠形态,并恢复了E-cadherin的分布.
- BHB提高了克劳丁-1生成的调节,并改善了其在结肠表皮中的分布.
结论:
- 在LPS诱导的全身炎症中,BHB可能会减轻肠上皮的透性.
- 在结肠中克劳丁-1的升级似乎是BHB保护作用的关键机制.
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