在缺血性中风后,基于共价有机框架的细胞保护疗法
Yuqin Peng1, Qingfan Ren2, Huanrong Ma3
1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Redox biology
|March 5, 2024
概括
这项研究开发了一种使用共价有机框架 (COFs) 的新型药物递送系统,以改善急性缺血性中风 (AIS) 的细胞保护. 通过针对活性氧物种 (ROS) 和SUR1-TRPM4通道,S/G@COF疗法有效降低了脑损伤.
科学领域:
- 神经科学是一个神经科学.
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 急性缺血性中风 (AIS) 导致严重的脑损伤,通常由活性氧物种 (ROS) 和SUR1-TRPM4通道加剧.
- 目前的治疗方法面临的局限性是由于低生物利用度的药物,如糖化物 (GLB).
研究的目的:
- 开发一种新的药物输送系统,以增强AIS的细胞保护.
- 克服GLB的生物可用性问题并减轻ROS引起的损害.
主要方法:
- 甘化物 (GLB) 和超氧化物脱酶 (SOD) 被封装在一个稳定的,多孔的共价有机框架 (COF) 中,形成S/G@COF.
- 在AIS模型中评估了S/G@COF的治疗疗效,评估了神经功能,脑,神经炎症和BBB完整性.
主要成果:
- 在AIS模型中,S/G@COF显著提高了存活率和神经功能.
- 治疗有效地消除了ROS,减少了神经元损失和亡,抑制了神经炎症,调节了微质激活,并改善了血脑屏障的破坏.
- 机制研究表明,S/G@COF激活了Wnt/β-catenin通路,同时降低了SUR1-TRPM4.4的调节.
结论:
- 使用COFs进行药物修饰为增强AIS中的细胞保护提供了一个有希望的策略.
- S/G@COF证明了缺血性中风治疗的多目标治疗潜力.
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