与糖尿病患者的其他肌肉群相比,较大的上肢肌肉质量与心血管死亡率降低有关
Chang Liu1, Lin Hua2, Zhong Xin1
1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Nutrition (Burbank, Los Angeles County, Calif.)
|March 5, 2024
概括
糖尿病患者上肢肌肉质量较高与心血管死亡风险降低有关,特别是在男性中. 这一发现凸显了区域肌肉分布对糖尿病患者治疗结果的重要性.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 身体组成分析 身体成分分析
背景情况:
- 肌肉质量及其分布是已知的预后因素.
- 区域肌肉质量与糖尿病心血管死亡率之间的具体关系尚不清楚.
研究的目的:
- 调查区域瘦肉量分布与糖尿病患者心血管死亡风险之间的关联.
- 确定哪些身体组成参数最能预测该人群中的心血管结果.
主要方法:
- 一项前性队列研究,使用美国国家健康和营养检查调查 (2003-2006,2011-2018) 中的2,166名糖尿病参与者的数据.
- 与国家死亡指数相关的数据用于追踪死亡率.
- 使用加权卡普兰-梅尔分析和多变量考克斯比例危险模型.
主要成果:
- 在各种瘦肉质分布水平 (上肢,下肢,骨头,骨干) 中观察到生存概率的显著差异 (P < 0.05).
- 上肢瘦肉量增加与心血管死亡风险降低有关 (HR,0.589;P = 0.041).
- 这种关联在男性中更为明显 (HR,0.378;P = 0.016).
结论:
- 较高的上肢瘦体质量独立地与糖尿病患者心血管死亡率较低有关.
- 保护作用在男性中尤为显著,这表明性别特异性差异.
- 需要进一步的研究,以了解肌肉代谢差异化的潜在机制.
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