量化药物-环极素复合的痛苦掩盖效应:NMR-ROESY混合时间方法
Tomohiko Ueda1, Mei S Yamaguchi1, Leela Christian-Tabak1
1Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-0022, Japan.
Carbohydrate research
|March 5, 2024
概括
药物 - 环极 (CD) 复合物有效地掩盖了苦味,改善了患者的服从性. NMR-ROESY分析与人类感官测试的相关性很好,证实了这些配方的苦味掩饰.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 物理化学 物理化学
背景情况:
- 患者的服从往往受到不愉快的药物味道,特别是苦味的阻碍.
- 药物-环德 (CD) 纳入复合体是提高药物溶解度和减轻苦味的常见策略.
研究的目的:
- 为了评估环极素 (CDs) 对各种药物的痛苦掩盖效果.
- 为了将药物-CD纳入复合体形成的强度与味道掩饰相关联.
- 评估NMR-ROESY,人体感官测试和电子舌头测量在评估苦味掩饰方面的实用性.
主要方法:
- 核磁共振 (NMR) 旋转框架Overhauser效应光谱 (ROESY) 用于调查药物-CD纳入复合物的形成.
- 进行了人类感官测试,以确定非苦味的药物CD配方.
- 进行电子舌头 (e-tongue) 测量以评估味觉检测.
主要成果:
- NMR-ROESY结果与人类感官测试结果有很强的相关性,其中较短的磁化传输时间表明有效的苦味掩饰.
- 人类参与者确定了特定的药物-CD纳入综合体,以掩盖苦.
- 电子舌头无法检测任何测试的药物CD含有复合物的味道.
- NMR-ROESY成功地确定了在多种药物系统中形成的特定药物-CD纳入复合体.
结论:
- 环极素 (CDs) 有效地掩盖了各种药物的苦味.
- NMR-ROESY是一种有价值的工具,用于预测和确认药物-CD纳入复合物的苦味掩饰.
- 结合NMR-ROESY和感官测试的多方法方法提供了对苦味掩饰的全面评估.
- 这些发现对制药配方有重大影响,提高了患者对药物的遵守和满意度.
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