不同的超声波参数对人体运动皮层的theta爆发横超声波刺激的不同超声波参数的影响
Ke Zeng1, Zhiwei Li2, Xue Xia3
1Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Zhuhai, Guangdong, China; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Brain stimulation
|March 5, 2024
概括
泰达爆发横超声刺激 (tbTUS) 在~5Hz时最佳地增加皮质刺激能力. 更高的工作周期和更长的持续时间增强了这些效应,改变了大脑的兴奋抑制平衡.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 人类的运动皮质
背景情况:
- 已知theta爆发横超声刺激 (tbTUS) 可以增加皮质刺激性.
- 对于tbTUS效应的最佳超声波参数在很大程度上仍未被探索.
研究的目的:
- 调查声学强度,脉冲重复频率,工作周期和超声波持续时间如何影响tbTUS效应.
- 确定诱导人类运动皮质刺激能力变化的最佳参数.
主要方法:
- 14名健康受试者参加了一项随机交叉研究,与8个不同的tbTUS会话进行了随机交叉研究.
- 使用运动唤起潜力 (MEP),静止运动值和对脉冲TMS测量方法评估皮层刺激性,直到刺激后90分钟.
主要成果:
- 大多数tbTUS条件增加了MEP振幅,5 Hz脉冲重复频率产生了比2或10 Hz更高的振幅.
- 增加的工作周期和更长的超声波持续时间延长了MEP振幅的增加.
- tbTUS减少了短期内皮层抑制,并增强了短期内皮层促进,而不会影响内皮层促进.
结论:
- 大约5Hz的Theta爆超声波对于在2-10Hz范围内增加皮质刺激性是最佳的.
- 在tbTUS诱导的可塑性中,存在于工作周期和超声波持续时间的剂量反应关系.
- tbTUS将运动皮层的抑制-激发平衡转移到更大的激发,为神经和精神疾病的治疗提供了潜力.
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