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人类牛奶成分和6个月的婴儿肠道微生物组:了解相互关联的关系
Maryam Kebbe1, Kartik Shankar2, Leanne M Redman3
1Faculty of Kinesiology, University of New Brunswick, Fredericton, New Brunswick, Canada.
The Journal of nutrition
|March 5, 2024
概括
人母乳中的成分,比如INTERLEUKIN-8 (IL-8),会影响婴儿的肠道细菌. 更高的IL-8水平与有益的肠道细菌多样性和组成相关,可能有助于免疫发育.
科学领域:
- 微生物组研究的研究.
- 婴儿营养 婴儿营养
- 免疫学 免疫学 免疫学
背景情况:
- 人类牛奶寡糖 (HMO) 影响婴儿肠道微生物群.
- 其他母乳成分对婴儿肠道细菌殖民的影响在很大程度上是未知的.
研究的目的:
- 调查母乳成分与婴儿6个月大时肠道微生物群多样性和组成之间的关联.
- 探索能量,宏观营养素,氨基酸,炎症标志物和激素在塑造婴儿肠道微生物群中的作用.
主要方法:
- 对54名母亲的横截面分析,这些母亲只吃母乳.
- 人母乳和婴儿便样本是在分娩后6个月收集的.
- 16S rRNA测序用于婴儿肠道微生物组分析和线性回归分析.
主要成果:
- 人类牛奶能量与肠道微生物群α-多样性负相关 (Chao1,Shannon).
- 洲际蛋白-8 (IL-8) 与肠道微生物群多样性和特定的细菌家族 (Bacteroidaceae,Bifidobacteriaceae) 和类 (Bacteroidetes) 有积极的关联.
- 氨基酸 (谷氨酸,血清素,异氨酸) 和其他炎症标志物 (IL-6) 也与特定的细菌种群有关.
结论:
- 人母乳IL-8可能会为婴儿的免疫系统提供有效的微生物反应.
- IL-8可能会促进有益的肠道细菌,并保护我们免受病原体的侵害.
- 特定的母乳成分显著影响婴儿肠道微生物组合.
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