根据世卫组织2017年分类,划分下垂体腺瘤的谱
Paul Paramita1, Rao Shilpa, B N Nandeesh
1Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Neurology India
|March 5, 2024
概括
免疫组织化学 (IHC) 有效地使用世卫组织2017年系统对垂体腺瘤 (PA) 进行分类. 这种方法有助于识别激进的PA和静音皮质形腺瘤,提高诊断准确度.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 世卫组织2017年对垂体腺瘤 (PA) 的分类整合了转录因子 (TF) 和激素表达.
- 根据这个更新的分类,有限的研究已经探索了PA的频谱.
研究的目的:
- 根据世卫组织2017年分类,划分下垂体腺瘤 (PA) 的频谱.
- 评估免疫组织化学 (IHC) 在分类PA中的实用性.
主要方法:
- 对2018年诊断的88例垂体腺瘤 (PA) 病例的回顾性分析.
- 使用H和E染色的组织病理学检查.
- 对于GH,PRL,ACTH,TSH,FSH,LH,CK,T-Pit和MIB-1的荷尔蒙免疫组织化学 (IHC) 进行检测.
主要成果:
- GH分泌腺瘤是最常见的功能性PA (68%).
- 淋巴腺腺瘤是最常见的非功能性PA (72.7%).
- 免疫组织化学在17%的病例中发现了侵略性腺瘤,包括静音皮质形腺瘤.
- 在T-Pit的阳性测试中,发现了静态皮质形腺瘤.
结论:
- 免疫组织化学 (IHC) 有效地对大多数垂体腺瘤 (PA) 进行分类,包括侵略性亚型.
- 添加T-Pit染色剂有助于识别静音皮质形腺瘤.
- 进一步纳入Pit-1和SF-1转录因子将改善多激素Pit-1PA和无细胞腺瘤的分类.
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