在H1N1感染中肌炎与肌危机相结合
Jayantee Kalita1, Sarvesh K Chaudhary1, Prakash C Pandey1
1Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Neurology India
|March 5, 2024
概括
像H1N1这样的感染可以在肌痛性严重肌痛 (MG) 患者中引发肌痛性危机 (MC),特别是肺炎和肌痛性肌痛炎. 及时评估肌肉参与对于在H1N1感染期间管理MG患者至关重要.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 感染是已知的肌痛性危机 (MC) 在肌痛性硬化症 (MG) 的原因之一.
- 肺炎和同时发生的肌肉干扰可能会加剧MG患者的MC频率和严重程度.
- 流感A (H1N1) 感染对MG患者,特别是那些接受免疫抑制治疗的患者构成重大风险.
研究的目的:
- 报告两例患有H1N1感染的骨髓灰质炎 (MG) 患者.
- 确定导致这些患者体质恶化和肌危机 (MC) 的关键因素.
- 强调评估MG患者患有H1N1相关肺炎的肌肉炎的重要性.
主要方法:
- 关于两名被诊断患有H1N1感染的肌痛性肌痛症 (MG) 患者的病例报告.
- 通过neostigmine测试,重复神经刺激和抗乙胆受体抗体测试,通过MG的诊断确认.
- 核酸检测证实H1N1感染;肌炎通过肌氨酸激酶水平评估.
主要成果:
- 一名患有H1N1,肺炎和肌肉炎的MG患者发生了严重的肌肉骨危机 (MC),需要10天的机械通风.
- 第二个患有H1N1但没有肌肉炎的MG患者没有经历MC,并在6天内完全康复.
- 这两名患者都在服用普雷迪尼索隆和阿扎西奥普林,并且之前没有接种H1N1疫苗.
结论:
- 除了肺炎外,肌肉炎还显著增加了H1N1感染的MG患者肌肉骨危机 (MC) 的风险.
- 肌肉炎的早期检测和治疗对于改善MG患者H1N1.1的治疗结果至关重要.
- 接种H1N1疫苗可能对MG患者有益,特别是那些接受免疫抑制治疗的人.
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