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Updated: May 6, 2026

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基于结构的泛冠状病毒抑制剂的设计,向宿主甲素L和calpain-1

Xiong Xie1,2, Qiaoshuai Lan3, Jinyi Zhao2,4

  • 1Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Signal transduction and targeted therapy
|March 5, 2024
PubMed
概括

两种新型化合物,14a和14b,有效抑制宿主蛋白酶Cathepsin L和calpain-1,对SARS-CoV-2变体和HCoV-OC43表现出广泛的抗病毒活性,具有有前途的抗炎作用.

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