在复发性耐火性多发性骨髓瘤中使用Teclistamab:多机构的现实研究
Meera Mohan1, Jorge Monge2, Nishi Shah3
1Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Blood cancer journal
|March 5, 2024
概括
在复发性/耐药性多发性骨髓瘤患者中,特克利斯塔马布的整体应答率为62%. 静脉注射免疫球蛋白预防显著降低了感染风险,突出了其在管理治疗并发症方面的重要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 多发性骨髓瘤 (MM) 是一种血液性恶性瘤,对于复发/耐药病例的治疗选择有限.
- 标准护理疗法正在不断发展,以改善患者的治疗结果.
研究的目的:
- 评估teclistamab在复发/耐药多发性骨髓瘤患者中的安全性和有效性.
- 评估应答率,无进展生存率和与德克利斯塔马布治疗相关的不良事件.
主要方法:
- 一个多机构的回顾性队列研究,包括110名患者,他们至少接受了一剂teclistamab.
- 分析整体反应率 (ORR),非常好的部分缓解率 (VGPR),无进展生存率 (PFS) 和细胞因子释放综合征 (CRS),免疫效应细胞相关神经毒性综合征 (ICANS) 和感染的发生率.
主要成果:
- 观察到整体响应率 (ORR) 为62%和≥非常好的部分缓解率 (VGPR) 为51%.
- 六个月无进展生存 (PFS) 为52%.
- CRS发生率为56%,ICANS为11%;感染发生在40%的患者中,26%的患者患有≥3级感染.
结论:
- 德基利斯塔马布在大量预先治疗的复发性/耐药性多发性骨髓瘤患者群体中显示出显著的疗效.
- 使用静脉注射免疫球蛋白 (IVIG) 的初级预防与感染风险明显降低有关.
- 现实世界的数据支持teclistamab作为一种可行的治疗选择,对CRS,ICANS和感染进行仔细监测至关重要.
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