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Updated: Jul 1, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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作为针对EGFR-TK的抗增殖剂的新型氧沙和皮拉衍生物:设计,合成,生物评估和分子对接研究

Marwa I Serag1, Samar S Tawfik2, Sahar M I Badr2

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. marwais@mans.edu.eg.

Scientific reports
|March 5, 2024
PubMed
概括

通过抑制EGFR-TK,新的氧沙和皮拉衍生物显示出强大的抗癌活性. 化合物10c在对抗癌细胞方面表现出显著的有效性,同时对正常细胞保持安全,其他候选药物显示出强烈的EGFR-TK抑制.

关键词:
它具有抗癌活性.对接研究对接研究在 EGFR 基因酶.氧迪亚二醇 (Oxadiazole) 是一种皮拉索林 (Pyrazoline) 是一种酸盐.

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