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重建人类原发性瘤的微环境:专注于瘤

Siwon Mun¹, Hyun Jin Lee¹, Pilnam Kim^2,3

¹Department of Bio and Brain Engineering, KAIST, Daejeon, 34141, South Korea.

Experimental & molecular medicine

|March 5, 2024

概括

传统的瘤模型无法捕捉到人体结构结构的复杂性. 重建瘤组织为癌症研究和精确医学提供了一条通往真正人性化的模型的道路.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
生物医学工程生物医学工程

背景情况:

瘤微环境 (TME) 包括对癌症进展至关重要的异质层细胞.
传统的瘤模型缺乏人体肌层的复杂性,限制了它们的翻译价值.
解决层层异质性对于推进癌症研究和精准医学至关重要.

研究的目的:

审查与瘤相关的 stromal 细胞的异质性.
总结一下解构方法来分离患者特异性的树皮细胞.
讨论解构对初级细胞特征的影响以及未来重建的瘤模型.

主要方法:

关于瘤解构和重建策略的文献综述.
在瘤微环境中分析 stromal 细胞异质性.
讨论创建体外人性化瘤模型的方法.

主要成果:

与瘤相关的 stromal 细胞表现出显著的异质性.
解构方法可以隔离患者特异性的树皮细胞,但可以改变细胞特征.
重建的瘤模型对更真实的体外研究有希望.

结论:

解构和重建瘤组织是体外建模的关键.
了解树皮细胞异质性和解构效应是必不可少的.
开发真实的人性化瘤模型需要仔细考虑这些因素.

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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...