休时间的久坐行为,体育活动,睡眠特征和近视之间的潜在因果关联:孟德尔的随机化研究
Xiao-Bin Zhang1, He-He Jiang1, Lin-Lin Zhang1
1Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
BMC ophthalmology
|March 5, 2024
概括
电脑使用增加了近视风险,而看电视和中度至强度的体力活动可能会减少近视风险. 睡眠特征和其他身体活动与近视发展没有显著的关联.
科学领域:
- 眼科和遗传学 眼科和遗传学
背景情况:
- 近视是一种普遍存在的折射误差,其全球健康影响越来越大.
- 生活方式因素越来越多地被认为对近视发病率和进展的影响.
研究的目的:
- 通过使用孟德尔随机化,研究休静坐行为 (LSB),体力活动 (PA) 和近视的睡眠特征之间的因果关系.
主要方法:
- 采用孟德尔的随机化 (MR),利用与LSB,PA和睡眠特征相关的遗传变异作为工具变量.
- 分析了来自大型全基因组关联研究 (GWAS) 的总结统计数据,包括英国生物银行,23andMe和FinnGen的暴露和近视.
- 应用多种MR方法,包括逆方差加权 (IVW),MR-Egger和加权中位数,以评估因果关系.
主要成果:
- 基因预测计算机使用与近视风险增加有关 (OR=1.057).
- 自我报告的中度至强度体力活动 (MVPA) (OR=0.962) 和看电视 (OR=0.973) 与近视风险降低有显著关联.
- 在基因预测的睡眠特征或加速计测量的体力活动与近视风险之间没有发现显著的关联.
结论:
- 计算机使用成为近视的重要危险因素.
- 电视观看和MVPA可能会对近视产生保护作用.
- 研究结果表明,潜在的生活方式干预可以减少近视的患病率.
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