新的炎症标志物和频繁的腹膜透析相关的腹膜炎之间的关联
Jing Tang1, Dongxue Wang2, Yun Chen3
1Department of Nephrology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
BMC nephrology
|March 5, 2024
概括
频繁的腹膜透析相关腹膜炎 (PDAP) 与炎症标志物有关. 该研究发现,全身免疫炎症指数 (SII) 和C反应性蛋白/高密度脂蛋白胆固醇 (CRP/HDL-C) 比率是频繁PDAP的关键指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床医学 临床医学
- 炎症研究 炎症研究
背景情况:
- 腹膜透析相关的腹膜炎 (PDAP) 是一个常见的并发症.
- 识别频繁PDAP的风险因素对于患者管理至关重要.
- 炎症在PDAP复发中发挥着重要作用.
研究的目的:
- 为了验证新的炎症标志物和频繁的PDAP之间的关联.
- 为了确定持续的门诊腹膜透析 (CAPD) 患者中复发PDAP的独立风险因素.
- 评估频繁PDAP的炎症标志物的预测价值.
主要方法:
- 对中国208名CAPD患者 (2010-2021) 的回顾性分析.
- 根据周周炎的间隔,患者被分为非频繁和频繁的PDAP组.
- 分析炎症标志物,包括系统性免疫炎症指数 (SII),CRP/HDL-C比率和其他临床数据.
主要成果:
- 在两组之间观察到透析时间,高血压,葡萄球菌感染,白细胞,中性粒细胞,淋巴细胞,血小板,SII,CRP/HDL-C,CRP,肌,BUN,,和透析中性粒细胞的显著差异.
- SII,CRP/HDL-C比率和糖尿病被确定为频繁PDAP的独立风险因素.
- 结合的SII和CRP/HDL-C显示了频繁PDAP的高预测值 (AUC=0.814).
结论:
- 该研究提供了临床证据,支持使用SII和CRP/HDL-C作为频繁PDAP的指标.
- 这些炎症标志物可以帮助识别患有复发性周周炎风险较高的患者.
- 这一发现对CAPD患者的积极管理策略有影响.
相关概念视频
01:24Chronic Pancreatitis I: Introduction
89
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
89
01:30Inflammatory Bowel Disease II: Crohn's Disease
244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
91
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
91
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
117
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
117
01:30Acute Pancreatitis II: Clinical Manifestations and Management
124
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
124