对正常响应者接受GnRH抗剂卵巢过度刺激方案的触发时间的元分析
Qijun Xie1, Danyu Ni1, Sisi Chen2
1Department of Reproductive Medicine, Nanjing Women and Children's Healthcare Hospital, Women's Hospital of Nanjing Medical University, No. 123 Tianfei Lane. Mochou Road, Qinhuai District, Nanjing, 210004, Jiangsu, China.
Journal of ovarian research
|March 5, 2024
概括
延迟激素释放激素 (GnRH) 抗剂协议中的触发射增加了卵细胞检索,但不会改善新胚胎移植的妇女的胚胎产量或怀孕率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 临床试验分析
背景情况:
- 在辅助生殖技术中,GnRH抗剂协议被广泛使用.
- 优化触发时间对于最大限度地提高妊娠结果至关重要.
- 之前的研究还没有全面评估延迟触发时间在该特定协议中的影响.
研究的目的:
- 为了评估延迟触发与标准触发相比,在接受GnRH抗剂方案的正常响应者中延迟触发的有效性.
- 评估推迟触发时间对关键妊娠结果的影响,包括临床妊娠率 (CPR) 和活产率 (LBR).
主要方法:
- 在主要数据库 (PubMed,EMBASE等) 进行了系统的文献搜索. 在2023年4月之前.
- 包括的研究是随机对照试验 (RCT) 和涉及使用GnRH抗剂协议的正常响应者的队列研究.
- 数据进行了元分析,以计算平均差异和几率比率,以95%的置信区间.
主要成果:
- 延迟触发组显示出明显更高的卵细胞检索数量和受精率.
- 在延迟触发组中,刺激的日子也明显长.
- 在延迟触发和标准触发组之间的胚胎数量,CPR或LBR中没有发现显著差异.
结论:
- 在GnRH抗剂协议中延迟触发射增加了卵细胞产量,但不会增强胚胎发育.
- 延迟触发时间在新鲜胚胎转移周期中对CPR或LBR没有显著的临床益处.
相关概念视频
Hormonal Control of the Ovarian Cycle
496
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
496
Hormonal Regulation of the Menstrual Cycle
369
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
369
Ovarian Cycle
1.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.2K


