在儿童和青少年注意力缺陷/多动症障碍的皮质干干因果关系分析
Fanyu Zhang1, Yilu Li1, Lin Liu1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Psychiatry and clinical neurosciences
|March 6, 2024
概括
注意缺陷/多动障碍 (ADHD) 显示大脑连接受损,特别是在条纹体和皮质之间. 年龄和诊断相互作用,影响视觉和默认模式网络,影响儿童和青少年的多动和冲动.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 条纹体和大脑皮层之间的有效连接在注意力缺陷/多动障碍 (ADHD) 中尚未完全理解.
- 调查皮质干道的途径对于理解ADHD病理生理学至关重要.
研究的目的:
- 探索诊断和年龄对ADHD中皮质底层有效连接的相互作用效应.
- 代表ADHD儿童和青少年改变连接的调制功能.
主要方法:
- 格兰杰因果关系分析应用于ADHD-200数据集中的300名参与者.
- 据估计,状体的输入和输出连接代表了互调机制.
主要成果:
- 在视觉和默认模式网络中发现了诊断和年龄之间的相互作用,与多动性/冲动性相关.
- 在多个网络中,ADHD通常表现出更高的皮质-状连接.
- 在ADHD中发现了一条涉及默认模式,条纹体,体运动和前端对象网络的信息通路中断.
结论:
- 视觉条形状-默认模式网络连接的改变可能与ADHD中的分心有关.
- 增加的因果连接和削弱的互调表明ADHD的运动规划和控制受损.
相关概念视频
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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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01:28Conduct Disorder
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Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
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01:19Autism Spectrum Disorder
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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