一种经过修改的地中海式饮食通过特定的肠道微生物组-大脑机制来增强大脑功能
Gwoncheol Park1,2, Saurabh Kadyan1,2, Nathaniel Hochuli1,2
1The Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Science, Florida State University, Tallahassee, FL, USA.
Gut microbes
|March 6, 2024
概括
一种经过修改的地中海质饮食 (MkD) 在阿尔茨海默病 (AD) 研究中显示出前景. 这种饮食对肠道微生物组产生积极影响,影响可能保护大脑和改善AD小鼠模型中神经认知功能的代谢物.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,其全球流行率不断增加,并且没有有效的治疗方法.
- 肠道-微生物组-大脑轴越来越多地被认为是其在神经系统疾病中的作用,包括AD.
研究的目的:
- 在AD小鼠模型中研究修改的地中海基因食 (MkD) 的疗效.
- 阐明MKD通过肠道微生物组和代谢组影响AD病理生理学的机制.
主要方法:
- 在转基因AD小鼠模型中利用了多omics方法.
- 分析了肠道微生物组合,微生物代谢产物和血清代谢产物的变化.
- 评估神经炎症,神经保护和神经行为结果.
主要成果:
- MkD显著改变了肠道微生物群,促进了乳酸菌并增加了乳酸盐的产生.
- 观察到微生物和饮食衍生代谢物的血清水平升高.
- 这些代谢物调节神经保护性受体,改变海马中的神经炎症路径.
结论:
- 在小鼠模型中,MkD对AD相关的神经功能表现出改善作用.
- 饮食调节肠道微生物组-代谢轴,影响肠道-大脑通信.
- 这些发现凸显了阿尔茨海默病中饮食干预的治疗潜力.
相关概念视频
Brain Imaging
229
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
229
The Blood-brain Barrier
47.3K
Overview
47.3K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
125
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
125
Role of Neurotransmitters in Memory
549
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
549
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331


