怀孕期间嗅觉皮层神经元变化的组织学分析
Ken Ichi Matsuda1, Tomoki Takahashi1, Sae Morishita1
1Department of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Heliyon
|March 6, 2024
概括
怀孕会改变大脑的神经元,影响嗅觉敏感度. 怀孕期间的荷尔蒙变化会影响嗅觉皮层的结构和功能,影响女性的气味感知.
科学领域:
- 神经科学是一个神经科学.
- 生殖生物学 生殖生物学
- 感官生理学 感官生理学
背景情况:
- 怀孕期间的嗅觉灵敏度波动与重症的超重症有关.
- 怀孕期间荷尔蒙环境的变化被假设在嗅觉系统中引起神经元变化.
研究的目的:
- 在大鼠模型中研究怀孕和产后嗅觉皮层神经元的结构和功能变化.
- 为了将神经元的变化与嗅觉敏感度的变化和荷尔蒙受体表达相关联.
主要方法:
- 在皮质皮质 (PIR) 和后侧皮质杏仁体 (COApl) 中量化了状脊柱密度.
- 免疫组织化学被用来分析雌激素受体α,催产素受体和益生素受体表达.
- 在嗅觉区域可视化了含有催产素的神经炎.
主要成果:
- 在怀孕中期的PIR和在怀孕早期和晚期的COApl中观察到树突性脊柱密度增加.
- 雌激素受体α阳性细胞在怀孕期间的PIR和怀孕期间和产后的COApl中减少.
- 在PIR和COApl中存在氧化素受体,与相应的含有氧化素的神经元,而前素受体则不存在.
结论:
- 怀孕引起的嗅觉皮层神经元结构变化与嗅觉灵敏度的改变相关.
- 荷尔蒙调节,特别是涉及雌激素和催产素信号传递,在孕期调节嗅觉感知方面发挥着重要作用.
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