在Tumaco (Nariño,哥伦比亚) 的第5社区疟疾流行率
Pablo Enrique Chaparro Narváez1, Monica Marcela Jimenez-Serna2, Maria Luz Gunturiz Albarracin3
1Observatorio Nacional de Salud, Instituto Nacional de Salud, Bogotá, 111321, Colombia.
F1000Research
|March 6, 2024
概括
哥伦比亚Tumaco的城市疟疾患病率低至2.97%. 关键因素包括家庭规模,需要采取战略来应对早期诊断和无症状的Plasmodium falciparum感染.
科学领域:
- 医学昆虫学 医学昆虫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 城市疟疾在哥伦比亚是一个重大的公共卫生挑战.
- 对城市疟疾流行病学的有限理解阻碍了有效的控制策略.
- 挑战包括识别城市病例并确保准确的诊断.
研究的目的:
- 为了估计城市Tumaco的疟疾发病率.
- 为了确定与疟疾感染相关的因素.
- 为了检测Plasmodium falciparum海斯蒂丁丰富的蛋白质2/3 (pfhrp2/3) 基因.
主要方法:
- 对来自526个家庭的1,504个人进行了分层的随机概率样本调查.
- 使用显微镜,快速诊断测试 (RDTs) 和聚合酶链反应 (PCR) 分析了血液样本.
- 使用后勤回归来分析相关因素.
主要成果:
- 总体疟疾患病率为2.97%,男性,10-19岁年龄组和无症状个体的患病率更高.
- 在2.16%的病例中检测到Plasmodium falciparum胺丰富蛋白2 (pfhrp2) 基因放大.
- 生活在三个或更多人的家庭中显著增加了疟疾风险 (ORa4.05).
结论:
- 图马科的城市疟疾发病率较低,主要是由菌菌引起的.
- 消除疟疾的战略需要适应城市环境,重点关注早期诊断的可访问性.
- 必须考虑无症状感染以及检测pfhrp2基因的RDTs的性能.
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