在混合饮食耐受性测试期间早期胰岛素分泌预测了囊性纤维化中β细胞功能和分泌能力
Saba Sheikh1, Darko Stefanovski2, Marissa J Kilberg3
1Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Frontiers in endocrinology
|March 6, 2024
概括
混合食耐受性测试 (MMTT) 准确地预测了葡萄糖增强阿尔金因 (GPA) 测试测量减少β细胞质量的囊性纤维化患者的β细胞功能. 这一发现支持MMTT作为评估β细胞分泌能力的可行替代方案.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 囊性纤维化研究 囊性纤维化研究
背景情况:
- 胰岛素分泌在胰腺功能不全的囊性纤维化患者中减少,随着葡萄糖耐受性受损而下降.
- 葡萄糖增强氨酸 (GPA) 试验量化β细胞的分泌能力,但在技术上要求高且繁重.
- 准确评估β细胞功能对于管理囊性纤维化中的代谢并发症至关重要.
研究的目的:
- 为了比较混合饮食耐受性测试 (MMTT) 中的胰岛素分泌与囊性纤维化 (PwCF) 患者的GPA衍生参数.
- 评估MMTT的可行性,作为评估PwCF中的β细胞功能的GPA测试的更少负担的替代方案.
主要方法:
- 涉及PwCF (胰腺不充分[PI-CF]和胰腺充分[PS-CF]) 和非CF对照的前性研究的二次数据分析.
- MMTT涉及计算胰岛素分泌率 (ISR) 和曲线下的增量面积 (AUC).
- 在各种高血糖条件下测量了GPA参数 (急性胰岛素和C反应). 使用相关性和Bland Altman分析来比较MMTT和GPA措施.
主要成果:
- 在MMTT期间的早期胰岛素分泌 (ISR AUC30min) 与所有GPA衍生的胰岛素和C-反应正相关 (所有P<0.001).
- MMTT ISR AUC30min强烈预测了GPA参数,特别是在β细胞分泌能力较低的水平上.
- 在不同研究组和葡萄糖耐受性类别中,MMTT和GPA措施之间的一致性是一致的.
结论:
- 通过MMTT测量早期胰岛素分泌可以准确预测GPA衍生的β细胞功能和分泌能力,特别是当功能β细胞质量减少时.
- 在PwCF中,MMTT提供了一种可靠,标准化和技术可行的方法来量化β细胞功能.
- 这些发现支持在未来的多中心研究中使用MMTT来评估囊性纤维化中的β细胞功能.
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