体与脂质体对比:在小鼠静脉注射后进行的比较性药理动力学分析
Shima Bahri1, Erfan Abdollahizad1, Iman Mahlooji1
1Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iranian journal of pharmaceutical research : IJPR
|March 6, 2024
概括
血体比脂质体具有更高的稳定性,但需要聚乙烯糖醇 (PEG) 进行长期循环. 这项研究比较了它们的药理动力学,发现PEGylated cerasomes与脂质体相比,突出了cerasomes的临床潜力.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与脂质体相比,体体表现出优越的物理化学稳定性和处理能力,这是由于它们的外部氧网.
- 这种增强的稳定性表明,在药物输送应用中,状体具有潜在的优势.
研究的目的:
- 为了比较静脉注射后体和脂质体的药理动力学 (PK).
- 为了评估PEGylation对基酶PK的影响,并确定单独的西洛网络是否可以延长循环时间.
主要方法:
- 用硫化银量子点 (Qds) 装载的PEGylated和非PEGylated质体和PEGylated脂质体的制造和表征.
- 静脉注射Qds和配方给大鼠,并采取72小时的血液样本.
- 使用非分区方法计算PK参数.
主要成果:
- 体和脂体载体都显著改善了Qds的PK配置文件,而不是自由的Qds.
- 基化体和脂质体表现出相似的PK概况,关键参数没有显著差异 (t1/2,AUC0-∞).
- 与非PEGylated cerasomes相比,PEGylated cerasomes的t1/2增加了1.6倍,AUC0-∞的AUC0-∞增加了3.3倍.
结论:
- 体在PEGylated时提供与脂质体相比较的PK性能,结合优越的物理化学稳定性.
- 仅仅在细胞体上的水友性氧网络不足以实现长时间的血液循环.
- 体由于其稳定性和功能性,在临床应用中是脂质体的有希望的替代品.
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