疼痛对人类皮质恒常性可塑性的影响:系统性审查
Daniela M Zolezzi1, Dennis B Larsen1, Megan McPhee1
1Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Pain reports
|March 6, 2024
概括
疼痛会损害家庭静止可塑性 (HP),这是一个调节皮质刺激 (CE) 的大脑机制. 这次审查发现,在刺激刺激缺乏疼痛状态后,CE减少,这表明慢性疼痛中的HP功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 神经可塑性 神经可塑性
背景情况:
- 恒常性可塑性 (HP) 是一个关键的负反系统,调节皮层刺激性 (CE).
- 在实验和慢性疼痛条件下观察到HP损伤.
- 了解HP在疼痛中的作用对于开发有针对性的疗法至关重要.
研究的目的:
- 系统地审查疼痛对人类皮质HP的影响.
- 综合有关实验性或慢性疼痛患者与健康对照患者的HP反应的研究结果.
主要方法:
- 对Scopus,Embase和PubMed数据库进行系统的文献搜索.
- 纳入标准:比较疼痛状况与对照者的研究,使用双块刺激来诱导HP,并测量CE (例如,运动唤起的潜能).
- 分析了4项涉及146名参与者的研究 (63例慢性疼痛,48例实验性疼痛).
主要成果:
- 有证据表明,疼痛状态中的HP受损,其特点是缺乏CE降低,其次是通过初级运动皮层进行刺激性-刺激性HP诱导.
- 不管疼痛状态如何,抑制性-抑制性HP诱导并没有产生一致的反应.
- 在疼痛和无疼痛状态之间观察到HP反应的显著差异.
结论:
- 在经历疼痛的个体中,皮质HP明显受损.
- 进一步的研究需要标准化的HP协议来进行可靠的比较.
- 研究诸如 nociception 这样的感官领域可以阐明疼痛中的异常HP调节.
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