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由于Candida nivariensis的原因,发生了三例 vulvovaginal 候群病例

Phuong Anh Ton Nu¹, Thi Minh Chau Ngo¹, Cao Le Chi¹

¹Department of Parasitology, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue City, 49000, Viet Nam.

Medical mycology case reports

|March 6, 2024

概括

耐药酵母菌Candida nivariensis是一种耐药酵母菌,会导致感染. 虽然一般对抗真菌药物敏感,但有一个病例表现出可纳耐药性,用更高剂量成功治疗.

科学领域:

医学真菌学医学真菌学
传染性疾病传染性疾病
抗微生物耐药性抗微生物耐药性

背景情况:

甘菌 (Candida nivariensis) 是一种新兴的酵母物种,属于甘菌 (Candida glabrata) 综合体.
这种物种越来越多地被认为是导致难以治疗的侵入性和粘膜皮肤感染的原因.
高抗真菌耐药性是这个病原体日益关注的问题.

研究的目的:

描述由Candida nivariensis引起的 vulvovaginal 候群病的临床病例.
为了评估Candida nivariensis分离物的体外抗真菌敏感性概况.
报告感染Candida nivariensis的患者的治疗结果.

主要方法:

使用内部转录间隔器1-2测序识别Candida nivariensis分离物.
在体外抗真菌敏感性测试与抗真菌剂小组对比.
临床病例报告和治疗结果分析.

主要成果:

鉴定了三例归因于Candida nivariensis的 vulvovaginal 候群病例.
所有分离物体都在体外表现出对anidulafungin,micafungin,caspofungin,5-flucytosine,posaconazole,voriconazole,itraconazole和amphotericin B.的敏感性.
观察到对可纳的剂量依赖性敏感性,其中一名患者发展出临床耐药性和复发,通过增加可纳剂量来控制.

结论:

尼瓦里菌 (Candida nivariensis) 是 vulvovaginal 候群病的重要原因,具有令人担忧的耐药性.
虽然许多抗真菌药物是有效的,但可纳的敏感性可能是可变的.
对于耐药病例,可能需要调整治疗策略,包括剂量升级.

关键词:

在Candida nivariensis中使用.弗卢可纳醇是一种 Vulvovaginal 候选症的发生

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