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在患有多发性硬化症的老年患者中,力量训练对神经退行,神经肌肉功能和身体功能的影响. 在老年多发性硬化症患者 (PoTOMS) 随机对照试验中进行"力量训练"的研究协议

Tobias Gaemelke¹, Christoffer Laustsen², Peter Feys³

¹Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.

Contemporary clinical trials communications

|March 6, 2024

概括

这项研究调查了患有多发性硬化症 (MS) 的老年人进行动力训练. 它旨在确定这种炼是否能改善这个人群中的大脑健康和身体功能.

科学领域:

神经学神经学
运动生理学运动生理学
老年学是一门学科.

背景情况:

多发性硬化症 (MS) 影响着老年人群,大约三分之一的MS患者 (pwMS) 超过60岁.
衰老和MS独立地损害大脑形态,神经肌肉功能和身体功能.
力量训练是一种高强度的抵抗运动,有望改善身体和神经肌肉功能以及大脑形态.

研究的目的:

为了评估24周的力量训练对老年 pwMS 的影响.
评估力量训练对整个大脑缩率的影响作为主要结果.
探索二次结果,包括大脑结构,神经肌肉和身体功能,认知,骨健康和患者报告的结果.

主要方法:

"老年多发性硬化患者的力量训练 (PoTOMS) "试验是一项全国性的多中心随机对照试验.
30名老年pwMS接受了通常的护理,而30名接受了通常的护理加上24周的力量训练.
主要结局:整个大脑缩率. 二次结果:大脑微/宏结构,神经肌肉功能,身体功能,认知功能,骨健康,以及患者报告的结果.

主要成果:

数据收集和分析正在进行中.
目前没有结果可用.

结论:

波托姆斯试验将为老年PWMS的力量训练的有效性提供关键的见解.
结果可能会为运动指南提供信息,以减轻与年龄和MS相关的衰退.
这项研究解决了理解力量训练在这个特定人口群体中的影响的差距.

关键词:

多发性硬化症是多发性硬化症.衰老的衰老衰老的衰老神经保护神经保护耐力运动是一种抵抗运动.

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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.