在阿尔茨海默病的语言和视觉变体中的纵向默认模式子网络
Irene Sintini1, Nick Corriveau-Lecavalier2, David T Jones1,2
1Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Brain communications
|March 6, 2024
概括
在阿尔茨海默病 (AD) 中的默认模式网络中断影响非典型变体类似于amnestic AD. 连接性变化,特别是在腹腔网络中,与病理和年龄有关,对年轻的阿兹海默症患者的影响更为严重.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是指放射学
- 老年学是指老年学的学科.
背景情况:
- 默认模式网络 (DMN) 的破坏是阿尔茨海默病 (AD) 的特征,但在非典型的AD表型中研究较少.
- 研究AD的视觉和语言变体提供了超出典型记忆缺陷的DMN改变的见解.
研究的目的:
- 为了检查视觉 (后皮层缩) 和语言 (逻辑性渐进性失语) 的AD变体的横截面和纵向DMN子系统变化.
- 为了将这些DMN变化与年龄和病理相关联.
- 为了比较非典型AD的DMN连接性与amnesticAD和认知正常的个体.
主要方法:
- 结构性MRI,静止状态功能性MRI和[18F]flortaucipirPET扫描用于61名粉样蛋白阳性AD参与者 (33名PCA,28名LPA) 和对照组.
- 双回归分析计算了DMN子系统连接 (后部,腹部,前腹部,前背部).
- 线性混合效应模型和基于voxel的分析评估了横截面和纵向变化,考虑到年龄和tau PET吸收.
主要成果:
- 与对照人群相比,非典型的和失忆的AD都显示后部/腹部连接性减少,前部背部DMN连接性增加.
- 年龄产生了相反的效果:随着对照组年龄的增长,连接性下降,但在年轻的AD参与者中较低,特别是在腹部DMN中.
- 在非典型的AD中,较高的TAU PET吸收与下腹/前腹DMN连接相关;腹部DMN连接在纵向下降,特别是在具有较低TAU的老年参与者中.
结论:
- DMN连接中断是非典型和无记忆性AD变体的共同特征,将AD与健康对照区分开来.
- 非典型的AD呈现下降的后部和增加的前部DMN连接,在年轻人中更为明显.
- 在非典型的AD中,腹部DMN连接的纵向下降表明与tau病理相关的转变,与DMN中断相关的视觉空间症状.
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