通过以为媒介的终端基二聚化来捕获机械互锁的分子
Thomas M Hood1, Samantha Lau1, Adrian B Chaplin1
1Department of Chemistry, University of Warwick Gibbet Hill Road Coventry CV4 7AL UK tom.m.hood@warwick.ac.uk a.b.chaplin@warwick.ac.uk.
RSC advances
|March 6, 2024
概括
过渡金属催化使得从终端基中有效合成合的1,3-氨酸. 这种方法被扩展到创建新的基于碳化合物的罗塔克桑和卡特纳因,使用宏环链接体.
科学领域:
- 有机化学 有机化学
- 超分子化学 超分子化学
- 催化剂是一种催化剂.
背景情况:
- 过渡金属催化基二聚化是合成合1,3-氨酸的一个关键反应.
- 在现代化学中,原子经济合成路径是非常可取的.
- 机械互锁分子 (MIMs) 的构造,如罗塔克桑和卡泰南,带来了重要的合成挑战.
研究的目的:
- 开发一种新的方法,通过过渡金属介导的基二聚化合成合的1,3-.
- 将这种方法扩展到以碳化合物为基础的罗塔克桑和卡泰南的构造.
- 在模板合成中探索基于氨酸的宏循环器联体的实用性.
主要方法:
- 由过渡金属催化的终端基二元化.
- 作为一个关键组件,利用基于氨酸的宏环形器连接体.
- "活性"金属模板合成,用于罗塔xane 的形成.
- 连续的"主动"和"被动"金属模板程序用于连锁合成.
主要成果:
- 通过原子经济二元化过程成功合成合的1,3-.
- 使用"活性"金属模板方法证明罗塔xane合成.
- 通过顺序的"主动"和"被动"金属模板,成功合成了catenane.
- 形成基于纯碳化合物的新型相互锁定分子.
结论:
- 基于氨酸的宏环链接剂在过渡金属中介的基二分化中有效.
- 这种方法为结合的1,3-和机械互锁的分子提供了一条通用的途径.
- 开发的战略为构建复杂的超分子架构提供了新的途径.
相关概念视频
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Introduction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
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02:38Electrophilic Addition to Alkynes: Halogenation
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02:47Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation
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02:24Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
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