甲基酸会导致慢性异性肺炎
Dhafer Alghamdi1, Hamdan Jahdali1, Abdullah Alharbi1
1Department of Pulmonology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Annals of thoracic medicine
|March 6, 2024
概括
甲基胺,一种治疗注意力缺陷多动症的药物,可能会导致eosinophilic肺炎. 这种罕见的疾病涉及肺炎,在停止服用药物后得到改善.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 注意缺陷多动症 (ADHD) 通常用兴奋剂药物治疗.
- 甲基酸盐是一种广泛处方的中枢神经系统兴奋剂,用于ADHD.
- 药物诱导的肺损伤是各种药物的公认但不常见的副作用.
研究的目的:
- 报告一种可能由甲基酸诱导的eosinophilic肺炎病例.
- 强调在呼吸道症状中考虑药物副作用的重要性.
- 强调在疑似药物诱导的肺损伤时,支气管洗和活检的诊断实用性.
主要方法:
- 一个38岁的男性患者的病例报告,他患有多动症和多动症在甲基酸盐.
- 临床评估包括胸部成像 (地面玻璃不透明) 和支气管镜检查.
- 支气管支气管洗液 (乙素细胞数) 和横支气管活检的分析.
- 通过药物戒断和重新挑战来评估药物因果关系.
主要成果:
- 患者呈现出渐进的呼吸短促和咳.
- 胸部成像显示了双边地面玻璃不透明.
- 支气管支气管洗显示了15%的乙氨基酸计数,活检证实了乙氨基酸性肺炎.
- 症状随着类固醇治疗和甲基化物停止而消失,并在甲基化物再次挑战时复发,伴随着皮疹.
结论:
- 甲基酸盐被强烈认为是这种患者患有eosinophilic肺炎的致病剂.
- 这一案例强调了兴奋剂药物诱导罕见肺部不良事件的潜力.
- 临床医生应保持高的药物诱导肺部疾病的怀疑指数,在患者呈现出无法解释的呼吸道症状,而在甲基胺.
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