血清蛋白质学确定CSF1R是慢性鼻炎与鼻的术后复发的新生物标志物
Yan Niu1, Shouming Cao1, Maoxiang Luo2
1Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
The World Allergy Organization journal
|March 6, 2024
概括
血清中的生物标志物可以预测慢性鼻炎与鼻息肉 (CRSwNP) 复发. CSF1R显示出预测CRSwNP复发的潜力,与巨细胞M2极化有关.
科学领域:
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 经过手术后,常常会出现复发性带鼻息肉的慢性鼻鼻炎 (CRSwNP).
- 导致CRSwNP复发的机制尚不清楚.
- 识别预测生物标志物对于管理CRSwNP至关重要.
研究的目的:
- 为了确定与CRSwNP复发相关的血清蛋白生物标志物.
- 阐明CRSwNP复发的潜在机制.
- 研究候选蛋白在巨细胞两极分化中的作用.
主要方法:
- 对CRSwNP患者进行前性队列研究,随访2年.
- 血清蛋白质基因分析,以比较经常性与非经常性群体.
- 在血清和组织中对差异表达蛋白质 (DEPs) 的验证,包括巨关联研究.
主要成果:
- 血清蛋白质组学在复发组之间确定了不同的蛋白质配置文件.
- 在复发性CRSwNP患者中,CSF1R和CDC42水平升高,DHRS9水平较低.
- 血清和组织中的CSF1R与复发风险和M2巨细胞极化相关.
结论:
- 血清蛋白质特征可以表明CRSwNP术后复发风险.
- CSF1R是预测CRSwNP复发的潜在生物标志物.
- CRSwNP复发涉及CSF1R介导的M2巨细胞两极化.
相关概念视频
Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...


