明显的纤维细胞亚群与骨,大脑或肺内转移有关,在高级非小细胞肺癌中
Ke Xu1, Hao Wang1, Yu-Xia Zou1
1Department of Respiratory Oncology, Division of Life Sciences and Medicine, the First Affiliated Hospital of University of USTC, University of Science and Technology of China, Hefei, Anhui, China.
Clinical and translational medicine
|March 6, 2024
概括
与癌症相关的纤维细胞 (CAF) 在非小细胞肺癌 (NSCLC) 骨与大脑转移方面有所不同. 特定的CAF类型促进了不同的转移途径,为高级NSCLC提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 晚期非小细胞肺癌 (NSCLC) 经常转移到骨或大脑,大大降低了生存率.
- 了解NSCLC转移中的单细胞区别对于开发向疗法至关重要.
研究的目的:
- 为了研究骨,大脑或肺内转移的患者的原发性肺癌组织中的单细胞差异.
- 确定癌症相关纤维细胞 (CAF) 在NSCLC转移到不同器官中的作用.
主要方法:
- 14个先前未经治疗的先进NSCLC组织活检样本 (骨,大脑,肺内转移) 的单细胞测序.
- 在质量控制和双重删除后,分析了80,084个细胞.
- 细胞间信号网络分析,以探索CAF与瘤细胞的相互作用.
主要成果:
- 在横跨转移部位的纤维细胞群和功能中发现了显著的差异.
- 已经确定了三个CAF亚群:myCAF,iCAF和apCAF.
- 抗原呈现CAFs (apCAFs) 在骨转移中普遍存在,促进癌症干,而炎症CAFs (iCAFs) 则主导大脑转移,增强入侵.
结论:
- 这项研究揭示了NSCLC骨和大脑转移中的瘤细胞和CAF之间的直接相互作用.
- 确定了特定的CAF亚群及其相关的信号通路作为潜在的治疗点,以抑制转移.
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