在患有过度饮食谱障碍的女性中,白素-6的升高水平
Alexis A Campanile1, Lisa A Eckel2,3, Pamela K Keel3
1Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, Texas, USA.
The International journal of eating disorders
|March 6, 2024
概括
炎症,标志着升高的介质素-6 (IL-6),是专门与暴饮暴食谱障碍 (BESD) 独立于体重,肥胖或抑郁. 这一发现表明,免疫因素可能在饮食失调行为中起作用.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一种精神病学.
背景情况:
- 暴饮暴食谱系障碍 (BESD) 的特点是大量摄入食物的情节与失去控制,影响整个身体质量指数 (BMI) 谱系的个体.
- 以前的研究表明BESD和外周炎症之间存在联系,但研究往往缺乏足够的力量,并且无法控制身体脂肪和抑郁症等混因素.
- 众所周知,身体脂肪增加和抑郁症独立地促进炎症,这复杂化了对BESD炎症的先前发现的解释.
研究的目的:
- 调查与对照组相比,患有BESD的女性体内的血中白素-6 (IL-6) 水平,这是外周炎症的标志物.
- 为了确定BESD中IL-6的升高是否在控制体重指数 (BMI),身体脂肪和抑郁症后仍然存在.
- 探索IL-6与BESD中饮食障碍严重程度的临床/生物标志物之间的关联.
主要方法:
- 招募了94名女性的样本,包括73名BESD和21名对照,代表了广泛的BMI类别.
- 参与者接受了结构化临床采访,并采集了禁食血液样本,以使用酶相关的免疫吸收剂测定来测量IL-6度.
- 统计分析比较了不同组的IL-6水平,并检查了与BMI,肥胖,抑郁,瘦素和饮食障碍严重程度的相关性.
主要成果:
- 与对照组相比,患有BESD的女性的血IL-6水平显著更高.
- 这些升高的IL-6水平即使考虑到BMI,身体脂肪和抑郁症,也仍然显著.
- 血IL-6度与血瘦素,饮食障碍严重程度以及最大的自我报告过度饮食事件的大小正相关.
结论:
- 周围炎症,以升高的IL-6为标志,与BESD中失调饮食的存在独特相关,独立于体重,肥胖和抑郁症.
- 这项研究提供了第一个证据,将炎症与BESD中的饮食失调联系起来.
- 需要进一步的研究来探索神经炎症在BESD中改变饮食行为的机制中的潜在作用,并确定新的治疗点.
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