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仿生水凝促进伪岛屿的形成,以改善糖尿病小鼠的血糖控制

Shajun Zhu¹, Yang Xu^1,2,3, Yuxi Li⁴

¹Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226000, China.

ACS biomaterials science & engineering

|March 6, 2024

概括

使用新型水凝的三维生物打印成功封装了产生胰岛素的细胞 (IPC). 这种仿生方法恢复了糖尿病小鼠的血糖水平,显示了糖尿病治疗的前景.

科学领域:

生物医学工程生物医学工程
再生医学是一种再生医学.
内分泌学在内分泌学.

背景情况:

岛屿或β细胞移植是糖尿病的理想治疗方法.
三维 (3D) 生物打印为封装和移植β细胞提供了一个有希望的策略.
培养具有生理性的生物胰腺对于成功移植至关重要.

研究的目的:

构建一个5%GelMA/2%AlgMA混合水凝与胰腺生理硬性.
使用混合水凝封装和3D生物打印胰岛素生成细胞 (IPC).
评估3D生物打印IPCs在体内对糖尿病小鼠的血糖控制的有效性.

主要方法:

制造5%GelMA/2%AlgMA混合水凝,模仿胰腺生理硬度.
在水凝中封装IPC用于3D生物打印.
在体内移植3D生物打印结构到糖尿病小鼠模型.
在移植后评估血糖控制和IPC功能.

主要成果:

混合水凝表现出良好的细胞兼容性,并支持IPCs形成伪岛屿结构.
从封装的IPC中观察到增强的胰岛素分泌.
贝塔细胞素 (BTC) 通过改变表达分布在IPC分化和自我调节中的重要性得到了验证.
在体内移植迅速恢复了糖尿病小鼠的血糖水平.

结论:

使用仿生水凝对β细胞进行3D生物打印,是糖尿病治疗的一个有前途的平台.
开发的混合水凝支持细胞活力,功能和血糖控制.
进一步的开发可能会导致岛屿移植的临床应用.

关键词:

生物模拟式水凝糖尿病糖尿病患者糖尿病患者岛屿移植移植小岛移植信号传导的信号传导.组织工程是组织工程.

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