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影响COVID-19疫苗接种后不良事件的因素
Paola Villanueva1,2,3,4, Ellie McDonald2, Julio Croda5,6,7
1Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Human vaccines & immunotherapeutics
|March 6, 2024
概括
免疫接种后的不良事件 (AEFI) 根据COVID-19疫苗类型,剂量和国家而异. 澳大利亚的年轻女性报告了更多的反应,但AEFI没有影响疫苗的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 新型平台技术推动了COVID-19疫苗的开发.
- 了解疫苗在不同人群中的安全性和有效性至关重要.
研究的目的:
- 评估COVID-19疫苗免疫接种后的不良事件 (AEFI).
- 在疫苗类型 (ChAdOx1-S,BNT162b2,CoronaVac),剂量和国家 (澳大利亚,巴西) 中比较AEFI发病率.
- 确定影响AEFI的因素,并评估反应性和抗尖峰IgG抗体反应之间的联系.
主要方法:
- 嵌套队列研究涉及1302名医疗保健工作者接受同源的2剂COVID-19疫苗方案.
- 通过1219名参与者的疫苗反应问卷收集的数据.
- 统计分析以比较AEFI发病率并确定影响因素.
主要成果:
- 在疫苗类型之间,在第一剂和第二剂后,系统性反应发生率有显著差异.
- 年轻的参与者,女性和澳大利亚的参与者中,AEFI风险更高.
- 澳大利亚的参与者报告了比巴西更高的局部和全身反应率,无论疫苗类型如何.
- 之前的COVID-19感染没有影响AEFI风险.
结论:
- AEFI发生率受参与者的人口统计 (年龄,性别) 和COVID-19疫苗类型的影响.
- 在澳大利亚和巴西的参与者之间观察到AEFI的显著差异.
- 对于ChAdOx1-S或CoronaVac疫苗,AEFI对血清转化率没有显著影响.
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