一个中度活跃的防蛋白分子与冰的表面之间的长距离,水介导的相互作用
Joanna Grabowska1, Anna Kuffel1, Jan Zielkiewicz1
1Faculty of Chemistry, Department of Physical Chemistry, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland.
The Journal of chemical physics
|March 6, 2024
概括
抗蛋白 (AFPs) 与冰间接相互作用. 液态水介于抗蛋白之间的结合.
科学领域:
- 生物物理学的生物物理.
- 材料科学 材料科学 材料科学
背景情况:
- 抗蛋白 (AFPs) 防止冰晶的生长.
- 了解AFP与冰的相互作用对于冷保护至关重要.
研究的目的:
- 阐明第三类抗蛋白 (AFP III) 和冰之间的相互作用机制.
- 为了研究水在AFP冰结合中的作用.
主要方法:
- 使用了分子动力学模拟.
- 分析的重点是AFP III的结冰部位 (IBS) 和冰面.
主要成果:
- 通过液态水的介导,AFP III间接与冰相互作用.
- 水分子形成聚合物,将AFP III IBS与冰面相连接.
- AFP III采用了一种特定的方向,以有效地与新生冰形成气结合.
结论:
- 结合AFP-冰并不是随机扩散,而是水介导的远程相互作用.
- 这种机制在不同的AFP类型中保持,包括CfAFP.
- 其他AFP可能通过类似的水媒介途径与冰相互作用.
更多相关视频
09:43Identification of Plant Ice-binding Proteins Through Assessment of Ice-recrystallization Inhibition and Isolation Using Ice-affinity Purification
Published on: May 5, 2017
8.7K
09:32LabVIEW-operated Novel Nanoliter Osmometer for Ice Binding Protein Investigations
Published on: February 4, 2013
20.6K
相关概念视频
03:13Intermolecular Forces
58.3K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
58.3K
02:04Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
01:25Aquaporins
4.9K
Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
4.9K
02:35Noncovalent Attractions in Biomolecules
50.6K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
50.6K
02:28Intermolecular Forces in Solutions
33.6K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
33.6K
01:24Van der Waals Interactions
63.9K
Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.
63.9K