改变召回期对报告严重症状的影响:对实用多站点试验的分析
Roshan Paudel1, Andrea C Enzinger1, Hajime Uno1
1Dana-Farber Cancer Institute, Boston, MA, USA.
Journal of the National Cancer Institute
|March 6, 2024
概括
缩短电子症状管理 (eSyM) 的召回期减少了癌症患者的症状报告. 电子患者报告结果 (ePRO) 的这种变化可能会改善瘤护理中的症状跟踪.
科学领域:
- 在瘤学瘤学.
- 数字健康数字健康
- 患者报告的结果
背景情况:
- 电子患者报告结果 (ePROs) 在瘤学中的症状管理的最佳部署尚不清楚.
- 电子症状管理 (eSyM) 程序收集患者报告的症状.
- 在症状报告方面,从7天的召回期改为24小时的召回期.
研究的目的:
- 评估缩短召回期对eSyM程序中症状报告的影响.
- 评估报告中度至严重症状的可能性的变化.
主要方法:
- 使用一般化的线性混合效应模型进行中断时间序列分析.
- 对1692名患者和7823个eSyM评估的分析,围绕回忆期的变化.
- 单独分析化疗和手术队列,通过元分析估计整个研究的影响.
主要成果:
- 缩短召回期与手术患者报告严重症状的几率下降有关 (OR=0.65,P=.02).
- 在化疗患者中观察到中度至重度症状报告的减少 (OR=0.83,P=.02).
- 24小时的回忆减少了术后便秘的报告,但没有影响其他普遍的症状.
结论:
- 对于ePROs来说,更短的召回时间与中度至重度症状报告的减少有关.
- 根据ePRO数据的预期用途 (例如,症状管理与临床试验终点),最佳召回期的持续时间可能会有所不同.
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