益生菌可以抵消老鼠近端结肠中因慢性思普拉丁暴露而导致的形态和功能变化
Cristina Biagioni1, Chiara Traini1, Maria Simonetta Faussone-Pellegrini1
1Research Unit of Histology and Embryology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Journal of cellular and molecular medicine
|March 6, 2024
概括
益生菌保护肠道微生物群免受西斯的破坏性影响,预防胃肠道问题,改善化疗耐受性. 这项研究强调了益生菌作为减轻化疗诱导毒性的潜在策略.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 西斯普拉丁是一种抗菌素化疗药物,导致显著的急性和慢性胃肠道副作用.
- 这些副作用,包括粘膜炎和神经病变,由于西斯普拉丁的抗生素特性而加剧,从而诱导失生症和炎症.
- 保护肠道微生物群是减少化疗毒性和提高药物疗效的潜在策略.
研究的目的:
- 为了研究慢性西斯丁给药对小鼠近腹结肠的影响.
- 评估益生菌丰富的饮食对西斯胺诱导的结肠变化的保护作用.
主要方法:
- 在小鼠中,长期服用西斯丁.
- 一组小鼠接受了富含益生菌的饮食.
- 评估了靠近结肠的形态和功能变化,包括体重增加,便产生,粘液分泌和结肠收缩性.
主要成果:
- 西斯普拉丁诱导体重减轻,增加高的摄入量,减少便的产生和粘液的分泌.
- 益生菌改善了考林摄入量,便产量和粘液分泌的变化,但没有减肥.
- 西斯普拉丁降低了Cajal间歇性细胞中的自发性结肠收缩和Connexin 43表达,这些效应被益生菌部分逆转.
结论:
- 慢性西斯普拉丁的使用会对小鼠近壁结肠造成显著的功能和形态损伤.
- 益生菌补充剂部分地防止了西斯普拉丁诱导的结肠变化,可能是通过保护肠道微生物群.
- 益生菌是一种有前途的治疗方法,可以减轻与西斯普拉丁化疗相关的胃肠毒性.
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