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抗真菌耐药性的进化趋势:一个元分析

Xueke Niu^1,2, Abdullah M S Al-Hatmi^2,3, Roxana G Vitale^4,5

¹Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.

Microbiology spectrum

|March 6, 2024

概括

这项研究分析了318种真菌的抗真菌耐药性,揭示了耐药性模式往往与真菌的进化关系保持一致. 菌系学有助于预测对抗真菌药物的易感性.

科学领域:

菌类学菌类学是指菌类学.
抗微生物耐药性抗微生物耐药性
进化生物学进化生物学

背景情况:

了解各种真菌物种的抗真菌药物疗效对于有效治疗至关重要.
对众多真菌物种的野生类型抗真菌数据已公布,但需要全面分析.
菌系构为探索药物反应的进化模式提供了一个框架.

研究的目的:

对318种真菌物种发表的野生类型抗真菌数据进行全面的元分析.
为了可视化和分析最小抑制度 (MIC) 在真菌秩序层面的趋势.
将抗真菌耐药性模式与真菌遗传树进行比较,以探索进化关系.

主要方法:

对34个类的318种真菌物种的文献数据的元分析.
使用欧洲抗菌感应性测试委员会和临床和实验室标准研究所 (CLSI) 断点评估抗真菌剂 (安福特素B,素,亚醇,特尔比纳) 的敏感性.
与真菌遗传树进行MIC值和耐药性/易感性概况的比较.

主要成果:

在测试剂中,在真菌类*Hypocreales,Microascales*和*Mucorales*中观察到一致的耐药性.
基菌体类 (*Agaricales,Polyporales,Sporidiales,Tremellales,Trichosporonales*) 呈现出对醇的多重耐药性.
具有显著病原性物种 (*Onygenales,Chaetothyiales,Sordariales,Malasseziales*) 的序列通常对醇敏感.
菌类耐药性和易感性模式与家族遗传相关性有很强的相关性.

结论:

的抗真菌耐药性经常与遗传学距离有关,同一个顺序中的物种表现出类似的药物反应.
野生类型抗真菌数据的最大王国范围的比较支持真菌进化和药物相互作用之间的联系.
遗传学分析为预测整个真菌王国的抗真菌易感性提供了洞察力.

关键词:

抗真菌剂是一种抗真菌剂.断点断点断点断点人类的基因组学.电阻的阻力可以

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