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对单细胞RNA测序数据的重新分析不支持单细胞病毒1在小鼠非神经质细胞中的潜伏

Werner J D Ouwendijk1, Pavitra Roychoudhury2,3, Anthony L Cunningham4,5

  • 1HerpesLabNL, Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.

Journal of virology
|March 6, 2024
PubMed
概括

通过重新分析单细胞RNA测序数据,这项研究没有发现免疫细胞中无疹简单病毒1型 (HSV-1) 潜伏的证据. 最初的发现归因于受损的数据集和细胞死亡文物.

关键词:
延迟相关的转录 (LATs)疹简单病毒病毒.免疫细胞 免疫细胞延迟时间 延迟时间神经元神经元的神经元这就是 scRNA-Seqq.

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Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...