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接受疾病,而不是感知控制,与炎症性肠道疾病相关的残疾有独特的关联
Anouk Teugels1, Ilse van den Eijnden2, Bep Keersmaekers3
1Research Group Health Psychology, KU Leuven, Leuven, Belgium.
Journal of Crohn's & colitis
|March 6, 2024
概括
接受疾病显著减少了炎症性肠病 (IBD) 患者的残疾. 这突显了疾病接受是改善IBD患者结果的潜在治疗目标.
科学领域:
- 胃肠病学 胃肠病学
- 心理学 心理学 心理学
- 健康 结果 研究 研究 结果
背景情况:
- 炎症性肠病 (IBD) 显著影响患者的生活质量,残疾是疾病负担的关键方面.
- 心理因素,如疾病接受和感知控制,是慢性疾病中主观健康的关键预测因素.
- 在IBD中,残疾越来越被认为是一个关键的临床终点,需要进一步调查其决定因素.
研究的目的:
- 检查心理预测因素,特别是疾病接受和感知控制,与IBD相关的残疾之间的关联.
- 确定这些心理因素在多大程度上解释了IBD患者残疾的差异.
- 为了比较心理预测因素对患有活跃疾病的患者和临床缓解期患者残疾的影响.
主要方法:
- 对1250名IBD成年患者进行了横截面调查.
- 收集的数据包括临床和人口特征,疾病接受,感知控制 (使用主观健康体验模型问卷) 和IBD相关的残疾 (使用IBD磁盘).
- 进行了多次线性回归分析,以确定IBD相关残疾的预测因素在总样本和基于疾病活性的子组中.
主要成果:
- 心理预测因素除了人口和临床因素之外,还解释了IBD相关残疾差异的19% (R2adj 38%与19%,p < 0.001).
- 疾病接受在总样本 (β = -0.44,p < 0.001) 和缓解 (β = -0.47,p < 0.001) 和活跃疾病亚组 (β = -0.31,p < 0.001) 中显示出与减少残疾的最强相关性.
- 当与其他变量一起考虑时,感知控制不是残疾的重要预测因素.
结论:
- 接受疾病是与炎症性肠病患者残疾水平较低相关的重要因素.
- 这些发现支持探索疾病接受作为潜在的治疗目标,以减轻IBD管理中的残疾.
- 需要进一步的研究来开发和评估旨在提高IBD人口接受疾病的干预措施.
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