倾斜引起的,呼吸驱动的血压振荡:独立于巴罗反射-交感神经神经功能
Edward Grabov1, Patti Sullivan1, Siqi Wang2
1Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC-1620, Building 10 Room 8N260, Bethesda, MD, 20892-1620, USA.
静止会增加高频的血压振荡,即使是巴罗反射失效. 这项研究证实,呼吸驱动的血压变化是独立于静止性低血压中血管同情性巴罗反射调节的.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
- 呼吸系统对血压的影响 血压的影响
背景情况:
- 静止 (站立) 通常会增加血压 (BP) 的变化.
- 低频 (LF) 血压振荡与血管交感巴罗反射有关.
- 与呼吸相关的静止期间的高频 (HF) 血压振荡不太了解,特别是在巴罗反射失效中.
研究的目的:
- 为了研究静止体对频率域中BP变异性的影响.
- 评估在静止过程中增加的高压血压振荡是否独立于血管交感巴罗反射功能.
- 为了比较患有和没有神经性正静性低血压 (OH) 的患者的血压变化.
主要方法:
- 对73名参与者进行了缩血压变化的功率谱分析 (42名与神经性OH,31名对照).
- 参与者进行了5分钟的90度头部向上倾斜.
- 在倾斜之前,倾斜期间和倾斜后分析了BP记录;数据被记录转换为统计分析.
主要成果:
- 在所有受试者中,抬头倾斜显著增加了缩血压变化的HF功率 (p=0.001).
- 这种高频功率的增加在神经性OH和对照组中都类似.
- 与OH组相比,对照组在静止期间的LF功率明显高于OH组 (p=0.009).
结论:
- 静止稳定稳定地增加高血压血压变化,即使在血管交感巴罗反射失效的个体中也是如此.
- 这些发现支持这样一个假设:在静止过程中,呼吸驱动的血压振荡可以独立于巴罗反射调制发生.
- 这项研究证实了先前关于高压血压在静止性低血压中的BP变异性的病例报告的发现.
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